tag:blogger.com,1999:blog-196334975274806517.post7480144584154600018..comments2024-03-28T06:11:20.882-06:00Comments on Cooling Inflammation: Enteroviruses, Autoimmunity, DiabetesDr. Art Ayershttp://www.blogger.com/profile/01727664149735013259noreply@blogger.comBlogger34125tag:blogger.com,1999:blog-196334975274806517.post-9474605025014722232013-04-10T16:16:10.544-06:002013-04-10T16:16:10.544-06:00Dr. Ayers,
Thank you for this refreshing conversat...Dr. Ayers,<br />Thank you for this refreshing conversation – so informative and informed. <br /><br />OK, so I researched Hashimoto’s and Ord’s (I am of British descent) thyroiditis and reviewed the symptoms. Other than bouts of depression, which I tend to deny as I am prone to an upbeat outlook, and fatigue, which I can correlate with times of extreme gut flora malfunction, I waffle concluding that I’ve had thyroid problems. I have had some of the symptoms of hypothyroidism (cold intolerance, constipation, fatigue, depression) but not others (weight gain, low heart rate, decreased sweating, poor muscle tone, etc). I have been checked in the past, and found to be fine, but what tests exactly I cannot say. <br /><br />My brother was celiac as a child and nearly died. I was not diagnosed as celiac and in hindsight, our family lived with poorly functioning digestion as I was growing up. We ate meat and vegetables and yet starches, grains and sugar were also present.<br /><br />As a 3 year old, I had plastic surgery for my belly button that stuck out an inch or two. I wondered if that breach in my stomach wall would have started my vitiligo.<br /><br />Twelve years ago, I travelled to Indonesia for 4 months, got very sick, came home and didn’t fully recover before going to Mexico for 3 months. Needless to say, I had digestive issues for years.<br /><br />Antibiotics: I know I took antibiotics as a child. I recall painful ear infections until age 10 and am sure I received a few doses. I am guessing I had antibiotics at least 5 times as a child. As an adult, perhaps once in my twenties and then none until, very unfortunately, last fall, I took them for a urinary tract infection. In hindsight, I found this last winter (Pacific Northwest) very difficult. I was lethargic and the sun deprivation brought on a strong depression. I knew it was sun related, was taking Vitamin D, but it didn’t seem to make a difference. As you’ve surmised, my Vit D levels must be very low. I am looking into getting my levels tested.<br /><br />Thank you for clarifying your comment regarding FMT new flora and new diet. <br /><br />Until recently, I was eating a 90% anti-inflammatory diet, with the odd gluten-free bread and gluten-free pizza for fun. Not getting full relief from flares, I consulted with an Ayurvedic nutrition consultant, who based on my symptoms and constitution recommended a diet of well cooked soups of grains and beans. Despite my knowledge, I proceeded. Needless to say, after 5 days, my rosacea briefly went away and then flared with a vengeance. I returned to my base diet (vegetables and meat) this weekend, clearly aware that the previous 10% starches in my diet were causing the persistent flares. It was during my research this weekend that I discovered your website and FMTs. <br /> <br />Soluble fibre: I have eaten fruits and not noticed undigested foods. I rarely eat beans as they seem to hard on my digestion. I cannot say I have noticed undigested beans. I will start to note. I have always taken note of my bowel movements, but not made causal connections with recent meals. I am also going to eat some unchewed sunflower seeds to track my transit time – or do suggest something less hard and pointy? <br /><br />And finally, although I hadn’t made the connection, fish oil and vit D may cause flares. I will cut them both out again, reintroduce separately, and see.<br /> <br />So, thyroid, celiac, vitiligo and rosacea autoimmune diseases run in my family. I have the latter two. Finally not only are points connecting, but a viable achievable solution is clear: soluble fibre and, low to no starches with a focus of growing my gut flora.<br /><br />I cannot thank you enough for the sanity and intelligence in this conversation. <br />Clarehttps://www.blogger.com/profile/12598678457756697684noreply@blogger.comtag:blogger.com,1999:blog-196334975274806517.post-42755490142539407762013-04-09T12:49:35.789-06:002013-04-09T12:49:35.789-06:00Clare,
Celiac is not a typical food intolerance. ...Clare,<br />Celiac is not a typical food intolerance. It causes inflammation, presents antigen and wipes out gut bacteria that are needed to suppress autoimmunity. The result is the development of a series of autoimmune diseases, starting with inflammatory bowel and then Hashimoto's thyroiditis. Vitiligo and rosacea follow and the whole series is aggregated by medical treatment of the symptoms with antibiotics to kill off gut bacteria that are needed for the normal development of the remaining aggressive part of the immune system.<br /><br />Please comment on your antibiotic history. What about dental health?<br /><br />Familial symptoms similar to yours do not indicate genetic inheritance, but rather shared gut flora and diet. It seems clear that your mother also suffered from celiac that should have been treated rather than just removing her thyroid..<br /><br />I think that the diet you just described sounds perfect. I would like to hear that you understand the relationship between gut bacteria and soluble fiber.<br /><br />My experience of people who already have your symptom progression also have a ritual eating pattern to avoid rosacea flares. You didn't mention the veggies that I noticed, so I feared that you might do the FMT and then starve out the new bacteria with a ritual diet. I was merely waxing hyperbolic to make the point that new gut bacteria and a new diet go together.<br /><br />From my experience, it is not unusual for someone with rosacea and your history to respond to anti-inflammatory diet changes, such as fish oil, vit.D, with flares. Your gut flora are too compromised. What happens when you eat soluble fiber, e.g. apples or beans? Do they just increase stool volume and transit rate, with a decrease in symptoms as you feed your gut flora on soluble fiber, or do they pass through undigested?<br /><br />I think that you should be able to turn all of your symptoms around by fixing and feeding your gut flora and avoiding gluten. You should also get a transient repair with probiotics.Dr. Art Ayershttps://www.blogger.com/profile/01727664149735013259noreply@blogger.comtag:blogger.com,1999:blog-196334975274806517.post-79433554880013435272013-04-08T21:47:57.530-06:002013-04-08T21:47:57.530-06:00Dr. Ayers,
I updated my profile, so I am the Anon...Dr. Ayers,<br /><br />I updated my profile, so I am the Anon from above...<br /><br />Yes, you are correct; I have a wheat allergy/intolerance and have cut that out for almost 2 years now. I occasionally get contaminated when I eat out and am weary of anything that may have soy sauce in it. <br /><br />Two things you wrote that caught my attention: thyroiditis and my diet. My mother had her thyroid removed when she was a child, and has taken thyroid supplements all her life. How did you infer thyroiditis with rosacea/vitiligo? I haven't read anything that correlates the two, yet have a parent with a compromised thyroid. Would that have affected me? and hence be related to rosacea and vitiligo?<br /><br />Secondly, you said that once I get an FMT that I would have to change my diet immediately. Is a paleo diet not essentially the Anti-Inflammatory diet? Is how I am eating still causing inflammation? Well, it is as I still have break outs, but what am I not seeing?<br /><br />I eat meat, vegetables and almond milk. I fill my plate with 1/2 to 2/3 vegetables, the rest meat. No starchy vegetables. I cook with ghee and am generous with ghee (fat). Ghee has cooling properties, has a high smoke point, acts like Coconut oil. I am taking Vitamin D (increasing my does to 10,000 IU), O-3 fish oil and L-glutathione. And no fruits for the next year. Can you expand on what caused you to remark that my current diet would kill the new gut flora?<br /><br />Thank you!<br /><br /><br />Clarehttps://www.blogger.com/profile/12598678457756697684noreply@blogger.comtag:blogger.com,1999:blog-196334975274806517.post-89732177898802397062013-04-08T19:03:44.706-06:002013-04-08T19:03:44.706-06:00Unknown,
I would be very surprised if the cause of...Unknown,<br />I would be very surprised if the cause of all of your problems wasn't celiac/gluten intolerance. It is a major contributor to autoimmune diseases, typically starting with thyroiditis and producing either too much or too little thyroid hormone. I think that when you changed diets, you reduced the celiac symptoms and thereby reduced chronic inflammation.<br /><br />Your vitamin D is still probably low even though you supplement. Your gut flora, as you recognize, seems very damaged and is a major contributor. I think that you would also be wise to feed your gut flora with plenty of soluble fiber and avoid grains. <br /><br />I think that a fecal transplant would be a good idea, but you would also have to immediately change your diet to maintain the new gut flora, since your current diet would kill it.<br /><br />Keep in touch with your progress and questions.Dr. Art Ayershttps://www.blogger.com/profile/01727664149735013259noreply@blogger.comtag:blogger.com,1999:blog-196334975274806517.post-58270685925026983302013-04-08T12:49:52.825-06:002013-04-08T12:49:52.825-06:00Hi,
I listed to your talk on Jimmy Moore's Sh...Hi,<br /><br />I listed to your talk on Jimmy Moore's Show and read 25 of your posts over this past weekend. Finally, I feel I have read content that makes sense. <br /><br />I have vitiligo - a skin condition that is linked with Type 1 diabetes. I am quite thin so have never been tested for diabetes. I had no idea vitiligo was related to diabetes until this weekend. I have had the condition since I was 2 years of age.<br /><br />About three years ago, I developed rosacea - an inflammatory skin condition in the insulin resistant family of illnesses which you have written extensively about. <br /><br />Dr. Ayers, thank you so so much for this blog. I have learned so much and now know that the paleo-diet I am on is key. I have taken vitamin D on and off, never realizing it was a key factor in my complex array of gut flora breakdown.<br /><br />I have always had a bowel movement daily and would never have considered myself constipated. That said, I have read that people with rosacea have low orocecal transit time and I am now beginning to see that the Time foods spends inside me is longer. I am also starting to note that although I've been eating seared almost rare beef to heal my intestinal walls, I believe that causes me to be infrequently constipated. It's so frustrating trying to carry out a science experiment on myself while also attempting to live and enjoy life.<br /><br />I have contacted 2 doctors to investigate getting a fecal transplant. I have gone from incredulous, to sold in a weekend of research. It makes SO much sense to me, I could almost cry for the past three years I have spent banging my head against a wall of limited information to determine how to truly heal inflammation. <br /><br />Can you offer any comments on the potential links (obvious or not) between roasacea and vitiligo? I am about to cut fruit out of my diet due to their insulin causing effect.<br /><br />Again, *thank you* for offering your insights.Clarehttps://www.blogger.com/profile/12598678457756697684noreply@blogger.comtag:blogger.com,1999:blog-196334975274806517.post-55587027851133178662012-05-22T13:20:33.768-06:002012-05-22T13:20:33.768-06:00This allergen amino acid sequence you found in the...This allergen amino acid sequence you found in the enterovirus VP1 protein is extremely interesting!<br /><br />May I ask a question: <i>in addition to diabetes, would you say this finding has import for chronic fatigue syndrome (ME/CFS), which is strongly associated with enteroviruses?</i> <br /><br />Enterovirus VP1 protein is persistently present in ME/CFS patients, and is found much more commonly in these patients than in health controls. Reference: <a href="http://esme-eu.com/getfile.php/Files/Chia_and_Chia_2007%5B1%5D.pdf" rel="nofollow"><b>1</b></a> <a href="http://www.cfids-cab.org/MESA/Chia.pdf" rel="nofollow"><b>2</b></a><br /><br />And 50% of ME/CFS patients have autoantibodies to the M1 muscarinic receptor, which is found in the parasympathetic nerves (and these autoantibodies may conceivably be responsible for the disturbed autonomic nervous system function found in ME/CFS). Ref: <a href="http://www.ncbi.nlm.nih.gov/pubmed/12851722" rel="nofollow"><b>1</b></a><br /><br />Also, some very recent clinical research has found that ME/CFS can be put into remission by deleting a patient's B-cells, using the arthritis drug rituximab. This fact further suggests that ME/CFS has an autoimmune basis. Ref: <a href="http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0026358" rel="nofollow"><b>1</b></a><br /><br />So might this enterovirus allergen amino acid sequence be driving the autoimmune processes that may be present in ME/CFS?Hipnoreply@blogger.comtag:blogger.com,1999:blog-196334975274806517.post-66895811037548804692011-03-19T19:08:18.937-06:002011-03-19T19:08:18.937-06:00Axel,
If it has any significance to you, I rememb...Axel,<br /><br />If it has any significance to you, I remember my sister saying that she could not go out in sunlight prior to taking vitamin d as she would have an allergic type reaction. She could only tolerate the very early morning sun for a brief period of time.<br />I remember now, that is the reason I had suggested supplementing with vitamin D to her because I felt that if she could not go out in the mid day sun and was not taking vitamin D, then she must surely be deficient.<br /> Once she got her serum 25 OH D level up, she was able to tolerate sun exposure better.<br /><br />ArtAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-196334975274806517.post-13156686042091424772011-03-19T08:54:43.505-06:002011-03-19T08:54:43.505-06:00Thanks Anonymous for the info oan vitiligo and D3....Thanks Anonymous for the info oan vitiligo and D3.<br /><br />What I find strange is that people with vitiligo avoid the sun but treatments use UV light.Axelnoreply@blogger.comtag:blogger.com,1999:blog-196334975274806517.post-52065542610033234722011-03-18T23:07:25.957-06:002011-03-18T23:07:25.957-06:00Axel,
My sister has vitiligo and she had very good...Axel,<br />My sister has vitiligo and she had very good results with relatively high dose vitamin D supplementation. She weighs approximately 145 pounds and was taking 8,000 to 10,000iu per day. Her serum 25 OH D level reached the 65 ng/ml area. She started seeing improvement in her pigmentation after 4 weeks. I'm sure there are likely multiple causes and vitamin D may not help everyone, but if you are deficient or quite low anyway, the potential health benefits of getting toward that 65~70 ng/ml area may be a good idea for general health in many people.<br />On a related note, about 6 months ago, she had an allergic reaction to something and decided to discontinue all of her supplements just in case any of them were the cause. After about two months of no vitamin d supplements and little if any sun exposure, her vitiligo started to reappear although not nearly as bad as it had been. By that time she had recovered from her allergic reaction and restarted her vitamin D again. Shortly after that her vitiligo started to go away again.<br /><br /><br />ArtAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-196334975274806517.post-81171439477881097622011-03-18T19:38:04.829-06:002011-03-18T19:38:04.829-06:00If anyone have more suggestion for vitiligo please...If anyone have more suggestion for vitiligo please let me know.<br /><br />Would you suggest testing for celiac?<br />Multivitamin but no D3 high dose?<br /><br />ThanksAxelnoreply@blogger.comtag:blogger.com,1999:blog-196334975274806517.post-39420732808467806282010-03-27T12:57:52.951-06:002010-03-27T12:57:52.951-06:00Hi dr, i am a medical student with great interest ...Hi dr, i am a medical student with great interest in neuroendocrinology and immunology. Apart from that i have a chronic cytomegalovirus and enterovirus-coxsackie B infection and i am searching for different ways to combat it, especially the latest enterovirus infection that has caused a very difficult enteric inflammation and dilatation. <br />Do you have any ideas how could i approach a potential treatment?? My immune system is deteriorating and i cant figure out what to do, there is no direct anti-enteroviral drugs, and im trying some immunemodulators which are really strong on my body and dont see any results. large quantities of vitamin C shows some very very small improvement but nothing important.<br /><br />I am looking for some natural or herbal or antivirals or some other anti-interleukins or receptor fusion treatment or modulatorsAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-196334975274806517.post-3805885945777618902009-04-22T08:36:00.000-06:002009-04-22T08:36:00.000-06:00Seems like your blog spot is becoming more and mor...Seems like your blog spot is becoming more and more popular, good job Dr. Ayers =)<br />Interesting that you are talking about vitiligo. I just gave a project presentation involving c-kit receptor and a key regulating transcription factor of pigmentation called mitf. Affected skin areas from vitiligo patients show a significant downregulation of both c-kit and mitf protein. I am not very well read in the mechanisms behind autoimmune disease and how it is related to vitiligo but reports show that transcription factors (SOX9 & SOX 10) directly upstream of mitf are reactive to autoantigens found the serum of patients with hereditary disorder autoimmune polyendocrine syndrome type I.<br />Don't know if this fits into your area of research but I found it interesting how everything is connected.Bengtnoreply@blogger.comtag:blogger.com,1999:blog-196334975274806517.post-49277680413004407482009-04-16T10:36:00.000-06:002009-04-16T10:36:00.000-06:00Kevin,
Prostate cells have lots of interesting rec...Kevin,<br />Prostate cells have lots of interesting receptors, e.g. testosterone, estrogen, TRPM8 (cold/menthol). Testosterone-based inhibitors have been used, because prostate development is male-specific and so these inhibitors are logical. They work, temporarily, until the selection pressure results in testosterone independent growth.<br />Estrogen receptors (everywhere) is a new idea, so it wasn't tested. My impression is that this is a hot new area for pharmaceutical development. Soon, all boys will be getting rectal exams and be treated with the next big drug.<br />The moral of the story is that prostate problems are modern and related to diet and lifestyle.<br />Prostate problems point to inflammation and that is why older men have more prostate problems, because inflammation increases with age. <br />Symptoms of aging are mismanaged chronic inflammation.<br />The good news is that if you adjust your lifestyle to fix your prostate, you will age more slowly.<br />ArtDr. Art Ayershttps://www.blogger.com/profile/01727664149735013259noreply@blogger.comtag:blogger.com,1999:blog-196334975274806517.post-13259807411993973222009-04-16T10:02:00.000-06:002009-04-16T10:02:00.000-06:00Hi Dr A,
I read your March 29 article on estrogen...Hi Dr A,<br /><br />I read your March 29 article on estrogen and prostate inflammation. I was recently diagnosed with BPH. I read Shippen's book ten years ago, saying pretty much what your article says. Maybe it's simplistic, but suppressing estrogen through tamoxifen-type drugs makes sense. So why are drugs like Proscar used more commonly? And why would it cause estrogenic side effects, such as gyncomastia? Not looking for a medical opinion, just your personal opinion on these questions. <br /><br />TIA,<br /><br />kevinKevinhttps://www.blogger.com/profile/07024614852550817486noreply@blogger.comtag:blogger.com,1999:blog-196334975274806517.post-76103251886904967182009-04-09T05:45:00.000-06:002009-04-09T05:45:00.000-06:00Dr Ayers,Thanks you for your -very comprehensive- ...Dr Ayers,<BR/><BR/>Thanks you for your -very comprehensive- response. I was absolutely focused in food allergies, instead of bringing balance to inflammation.<BR/><BR/>The truth is that I don't think the "complete elimination of X, Y, Z" was making any difference and I am coming to a point where I may develop allergies for everything that I eat (as confirmed by ELISA tests... Lots of false positives, I know, but every time I do one of them more and more things will come back positive).<BR/><BR/>Thanks again and please keep it up with your blog, it's a great resource for both patients and scientists. <BR/><BR/>Best regardsAngelaNnoreply@blogger.comtag:blogger.com,1999:blog-196334975274806517.post-6488856363647119582009-04-09T00:10:00.000-06:002009-04-09T00:10:00.000-06:00That is a great article. It provides a skeptical ...That is a great article. It provides a skeptical perspective on the new vitamin D deficiency bandwagon (that I support.) It basically sets up a choice between the vitamin D deficiency and pervasive chronic infections as the basis for autoimmune diseases. Supplementation with vitamin D would be a disaster, if the infection model is true, because it would lead to an initial obscuring of symptoms followed by more severe relapse.<BR/><BR/>I find the article flawed by its characterization of the deficiency model as a simple switch triggered by vitamin D (forms) binding to the vitamin D receptor transcription factor and turning on innate immunity genes. I think that there are numerous vitamin D activated proteins, since the binding structure is very common and many extracellular proteins have beta-sheet jelly doughnut like structures that might bind steroids. So I fall into the stereotype of black box biochemistry that says that too little vitamin D leads to dysfunctions that trigger chronic inflammation and autoimmune diseases start from there.<BR/><BR/>That said, I also give credibility to the chronic infection models and the triggering of hibernation-like responses. Thus, some treatments with antibiotics may make sense for some autoimmune diseases, cancers, etc. We don't know enough for these treatments. After all, high dose aspirin has also been effective in some cases.<BR/><BR/>The article also makes reference to gut flora and I find that aspect very important as well.<BR/><BR/>So, the bottom line is a vague support for my general prejudices. The article says to beware of cures lacking clear explanations of the causes. That advice would eliminate the whole drug industry. I tend to avoid pharmaceuticals and lean toward sensible diet and exercise. At 60+ I can still do handstands and practice karate without joint pain or stiffness (as long as I stay on an anti-inflammatory diet.) If I eat American, I suffer just like everyone else.Dr. Art Ayershttps://www.blogger.com/profile/01727664149735013259noreply@blogger.comtag:blogger.com,1999:blog-196334975274806517.post-49901673994963416582009-04-08T22:39:00.000-06:002009-04-08T22:39:00.000-06:00Dr. Ayers,I'm curious as to your take on this pape...Dr. Ayers,<BR/><BR/>I'm curious as to your take on this paper, "Vitamin D: the alternative hypothesis," to be published in Autoimmunity Reviews, and available at http://autoimmunityresearch.org/transcripts/AR-Albert-VitD.pdf. It suggests that vitamin D might supplementation might be counterproductive in autoimmune conditions. What should we make of this?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-196334975274806517.post-13232632505025812452009-04-08T09:10:00.000-06:002009-04-08T09:10:00.000-06:00Hi Dr. Ayers,Thank you for the clarification -- pe...Hi Dr. Ayers,<BR/><BR/>Thank you for the clarification -- perhaps that explains why some cranberry juice UTI studies show efficacy while others bunk... Lectins are so curious to me -- like auto-antibodies, there are some studies that show lectins bind insulin receptors as well as structures like ovarian cells. Perhaps nature intended some sort of protective 'signal' (hibernation, hyper-immunity, ?) which now is going awry?<BR/><BR/>(I'm in the camp where 99.5% of the global populace are silent celiac or overt celiac.) Gluten-damage on the intestinal lining responds well to nutrients that boost immunity, removal of dietary toxins (gluten, sometimes casein) and replacing fat soluble vitamins (which are not absorbed while the gut is 'leaky' and damaged). <BR/>-Zn Se Bo Iodine Chromium etc<BR/>-Magnesium to keep blood levels 2.2 -2.3mg/dl<BR/>-B vitamins, folic acid, TMG, B6, sublingual B12, etc<BR/>-vitamin D (enough to bring blood to 25(OH)D 70 ng/ml or higher)<BR/>-vitamin A E K1 K2<BR/>-vitamin C<BR/>-EPA DHA fish oil (maybe try liquid Carlson's? tastes yummy, like lemon pledge, j/k)<BR/>-saturated fats (lauric acid, MCT, coconut oil, meat/fish, yolks, butter oil, etc) <BR/>-co Q10, alpha lipoic acid, carnitine, taurine, etc<BR/>-low carb, insulin-controlled diet<BR/><BR/>The role of digestive enzymes (to replace what the gallbladder is probably too damaged to make) and probiotics is highly beneficial as well. (Fungal overgrowth is sometimes a HUGE problem. Yeast die off can be an issue too.) <BR/><BR/>It's hard -- hope she feels better soon!<BR/><BR/>-GDr. B Ghttps://www.blogger.com/profile/15451872961651116061noreply@blogger.comtag:blogger.com,1999:blog-196334975274806517.post-86481425921743029562009-04-08T01:17:00.000-06:002009-04-08T01:17:00.000-06:00Dr. B G,I grew up with lectins and see them in rat...Dr. B G,<BR/>I grew up with lectins and see them in rather friendly terms. Structurally monomers are not related to the corresponding residue in a polymer, so an enzyme that binds mannose will not bind to a mannosyl residue in an oligosaccharide. Antibodies or lectin specific for mannosyl residues will bind mannose with less than 1% the affinity. Mannose and fructose in the diet will not have an impact on lectins binding to oligosaccharides.<BR/><BR/>I doubt that mannose in cranberry juice has any impact on bacteria binding to mannosyl residues of the urinary tract, unless large quantities of mannose are concentrated in the kidney and stored in the bladder. I would still be surprised if gut bacteria were impacted by the dietary mannose during this process.<BR/><BR/>I think that dietary supplement glucosamine has a metabolic impact on gut flora, but I remain skeptical of any lectin-mediated effects.<BR/><BR/>The vitiligo interaction is interesting. One of my students developed vitiligo, celiac and a string of food allergies. She is an expert at avoiding gluten, but still has lots of allergies. She recently developed an allergy to DHA/EPA capsules. Clearly her inflammation is not under control and her strange nutrient absorption makes it hard to determine the impact of supplements. What would you recommend?<BR/><BR/>Thanks for stopping by,<BR/>ArtDr. Art Ayershttps://www.blogger.com/profile/01727664149735013259noreply@blogger.comtag:blogger.com,1999:blog-196334975274806517.post-38273688581900665352009-04-07T23:25:00.000-06:002009-04-07T23:25:00.000-06:00Dr. Ayers,Again I really appreciate how Asclepius ...Dr. Ayers,<BR/><BR/>Again I really appreciate how Asclepius (of Natural Messiah blog) found you! <BR/><BR/>You are a GEM! Thank you for your explanations!<BR/><BR/>Dietary lectins may not be involved in fructose toxicity in mammals but how about the role of mannose and fructose in the exterior of viruses, bacteria and fungus? Can innate MBLs distinguish between mannose v. fructose? <BR/><BR/>I agree, fructose can cause autoimmune problems, like NASH (autoimmune fatty liver), via its damage from AGEs production (? probably accelerated by excessive omega-6 and lack of omega-3 and vitamin ADEK deficiencies?).<BR/><BR/>We have found that gluten elimination is highly effective in 'cooling inflammation' for CAD and a variety of autoimmune disorders (including osteoarthritis, diabetes Type 2, Hashimoto's, etc) at our heart disease reversal program. The gluten-genetic interaction appears to affect 99% of the population. For my family and I, eliminating gluten has produced immense anti-inflammatory benefits:<BR/>--my father-in-laws RA subsided and eliminated knee joint aches (some antioxidants speeded recover -- krill oil/astaxanthin (you've written about), pycnogenol)<BR/>--my daughter's vitiligo resolved<BR/>--IBS for several family members resolved completely<BR/>--my mood is calm<BR/>--my children halted ALL tantrums (which were rare anyway)<BR/><BR/>For my patients I've noticed 5 lb/month wt loss despite lack of exercise, resolution of body/joint aches, reduction in belly fat and decreased insulin requirements (or even complete elimination)!<BR/><BR/>I think I'll stay away from Mannose for now :)<BR/><BR/>THANK YOU AGAIN!<BR/>gDr. B Ghttps://www.blogger.com/profile/15451872961651116061noreply@blogger.comtag:blogger.com,1999:blog-196334975274806517.post-82302951983647840172009-04-07T17:17:00.000-06:002009-04-07T17:17:00.000-06:00Dr. B G,Thanks for your comments.I started working...Dr. B G,<BR/><BR/>Thanks for your comments.<BR/><BR/>I started working with lectins in host-pathogen interactions back in the early 70s. I found a glucan that would trigger plant disease resistance. Mannose could inhibit the response. Now supplements with that glucan are used to "stimulate the immune system". This probably means that it induces inflammation. Mannans seem to be anti-inflammatory.<BR/><BR/>Pathogen detection in mammals takes place in part by innate lectins, such as the mannosyl binding protein. Many pathogens bind to human cells by using their lectins to bind to human glycosyl residues. This makes sense, because sugar binding is a hydrophobic process that can release approx. 20 kcal/mol. Simple sugars are very much less effective than oligosaccharides in binding, so only situation such as the bladder, in which the pathogen will be swept away unless it adheres, will be affected by monosaccharides such as mannose.<BR/><BR/>Fructose has lots of other actions outside of the realm of lectin interactions. I doubt that dietary fructose has anything to do with lectins. It is much more important in advanced glycation endproducts, in which case it no longer chemically resembles fructose.<BR/><BR/>I also don't think that wheat lectins or any lectins are involved in celiac and gluten-based problems.Dr. Art Ayershttps://www.blogger.com/profile/01727664149735013259noreply@blogger.comtag:blogger.com,1999:blog-196334975274806517.post-91439547330714958422009-04-07T16:58:00.000-06:002009-04-07T16:58:00.000-06:00Kevin- the Vet,I must admit that I have more respe...Kevin- the Vet,<BR/><BR/>I must admit that I have more respect for vets than MDs. You guys are more pragmatic than ideologic.<BR/><BR/><BR/>I have no idea why Adequan would work as an injectible. I am convinced that glucosamine's effects are all in the gut. Gut administration of any of the GAGs (heparin, chondroitin, HA) or their monomers can't have an effect on connective tissue GAGs. Glucosamine is produced in most cells and having more available isn't going to impact GAG production. Besides, chondrocytes actively metabolize the GAGs in which they are embedded -- they burrow like moles. It is these tunnels of newly synthesized cartilage that repair torn or cut cartilage; chondrocytes stitch the cartilage together.<BR/><BR/>Your tennis elbow may respond better by chemical acupuncture in the form of castor oil. You can add menthol or capsaicin to stimulate the hot/cold sensor. All three work similarly to stimulate pain reduction and lower inflammation. Just coat the whole general area and pain should be gone in five minutes. You should be able to use that pain to monitor your overall inflammation.<BR/><BR/>I enjoy your comments.Dr. Art Ayershttps://www.blogger.com/profile/01727664149735013259noreply@blogger.comtag:blogger.com,1999:blog-196334975274806517.post-71462767096658315732009-04-07T16:42:00.000-06:002009-04-07T16:42:00.000-06:00Angela,Sorry I was so slow in getting back to you....Angela,<BR/>Sorry I was so slow in getting back to you.<BR/>Your symptoms do make you sound like the inflammation poster child.<BR/>I would suggest to focus first on vitamin D. You may be so inflamed that you have compromised your solar production. I would start with 5000 IU/day and take it throughout the day with meals (phytoantioxidants). I think that as much as 10,000/day is without side effects. This should also help oral health.<BR/><BR/>Dental problems are obviously major contributors to inflammation. Good oral health is essential -- brushing, flossing, etc. It sounds like you have more serious problems. Listerine with menthol, thymol, eucalyptol, etc. (blue) should be a big help. It is also anti-inflammatory.<BR/><BR/>Vitamin C -- It sounds like you have a big load of oxidation stress. I would expect that to lead to vitamin C depletion and deficiency. This would give you oral health problems. You might try increasing your vitamin C until you get bowel symptoms. That would mean trying 4000 mg/day to see if you can tolerate that much and then adjusting up or down.<BR/><BR/>Probiotics -- You have probably messed up all of your gut flora by producing food allergies as a result of high chronic inflammation. This will also mess up your B vitamin uptake. Start enjoying simple whole fat yogurt without sweetening. You can make very tasty Indian lasi drinks using a hand-held blender to mix yogurt and fresh/frozen fruit.<BR/><BR/>Your fasting is a master stroke, because it induces anti-inflammatory cytokines and lowers your blood sugar. Unfortunately, coming off your fast, even lower sugar meals will cause a big insulin boost. I would expect you to have trouble regulating your blood sugar. Low carb is the only approach. Switch to more small meals. Avoid starch, fruit juices, sugar. Enjoy meat and lots of spices -- turmeric, red pepper, black pepper.<BR/><BR/>Avoid all vegetable oils except olive oil. Try cooking with coconut oil and butter. Enjoy wild salmon frequently -- just broil with pats of butter and lemon juice.<BR/>Supplement with fish oil. You are already doing this, but are not benefiting, because of all of the other sources of inflammation.<BR/><BR/>MS results from inflammation that has broken down the blood brain barrier. Doing all of the above simple stuff should be a big help.<BR/><BR/>Physical activity is also a big help, so force yourself to increase your muscle mass. You need more than cardio.<BR/><BR/>Glucosamine should also help, once you have reestablished your gut flora -- 1,500 mg/day.<BR/><BR/>I can only help with this common sense approach. You still need to work with medical people, so find some people who have a clue. Some veterinarians may be more helpful.Dr. Art Ayershttps://www.blogger.com/profile/01727664149735013259noreply@blogger.comtag:blogger.com,1999:blog-196334975274806517.post-7218846876170522222009-04-05T11:34:00.000-06:002009-04-05T11:34:00.000-06:00Hi Dr. Ayers, I just found your blog yesterday and...Hi Dr. Ayers, <BR/><BR/>I just found your blog yesterday and am working my way through all of your previous posts. I look forward to reading any future postings. This has been a fantastic find for me. Thank You.<BR/>steveyyzAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-196334975274806517.post-90729454218694804512009-04-04T17:56:00.000-06:002009-04-04T17:56:00.000-06:00Hi Dr. Ayers,From a pharmacological perspective, y...Hi Dr. Ayers,<BR/><BR/>From a pharmacological perspective, your posts are eye-opening! I love your BLOG.<BR/><BR/>What are your thoughts on our immune system producing MBLs (mannose-binding lectins)? Like Stephan's hypothesis that glucosamine is effective by being a 'surrogate' target of a dysregulated immune system, it appears to me that mannose from let's say cranberry juice may be effective for Gram-neg (like E.coli) UTIs by providing mannose, in this case, by providing more 'surrogate' immune targets, heightening the bacterial triggered immune response (?).<BR/><BR/>Fructose and mannose are both carried on the outer membranes of invading bacteria and prokaryotes and programmed to be sensed by our sentinel immune system. Excessive fruit consumption (and HFCS, soda, juices) appears particularly detrimental to Autoimmunity, Diabetes and other inflammatory conditions (like wheat/gluten). I'd love to hear your thoughts...! <BR/> <BR/>(have to admit my immunology needs help)<BR/>Thank you!<BR/>GDr. B Ghttps://www.blogger.com/profile/15451872961651116061noreply@blogger.com