tag:blogger.com,1999:blog-196334975274806517.post6659926053461393075..comments2024-03-28T06:11:20.882-06:00Comments on Cooling Inflammation: National Healthcare and DietDr. Art Ayershttp://www.blogger.com/profile/01727664149735013259noreply@blogger.comBlogger29125tag:blogger.com,1999:blog-196334975274806517.post-20975423820398923772022-10-07T09:16:14.860-06:002022-10-07T09:16:14.860-06:00This is a great inspiring article. I am pretty muc...This is a great inspiring article. I am pretty much pleased with your good work. You put really very helpful information. Keep it up. Keep blogging. <a href="https://www.jacketscreator.com/product/the-munsters-herman-munster-jacket/" rel="nofollow">Herman Munster Jacket</a>andrewjacksonhttps://www.blogger.com/profile/18250263731201535375noreply@blogger.comtag:blogger.com,1999:blog-196334975274806517.post-91566248178000454512022-03-08T04:14:41.200-07:002022-03-08T04:14:41.200-07:00The city’s tourist industry was also the third-lar...The city’s tourist industry was also the third-largest in terms of revenue after leisure and accommodation services with some 1.2 billion annual visitor spending. 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To climb the second highest peak in the United Arab Emirates, <a href="https://desertadventuregroup.com/top-rated-attraction-places-of-uae/" rel="nofollow">Jebel Hafeet</a> is one of the most popular destinations for tourists and locals alike.<br /><a href="https://desertadventuregroup.com/top-rated-attraction-places-of-uae/" rel="nofollow">beaches at Khor Fakkan</a> is a must to experience the region’s amazing wildlife reserves. Those who want to visit the wonderful desert islands resort and spa of Anantara or want to enjoy a luxurious meal here.Travel loverhttps://www.blogger.com/profile/04073797292412235051noreply@blogger.comtag:blogger.com,1999:blog-196334975274806517.post-26680652909372733462021-05-04T14:08:05.881-06:002021-05-04T14:08:05.881-06:00This place in Al Ain City is a great place for mou...This place in Al Ain City is a great place for mountain lovers. The beautiful hilly terrain provides a great backdrop that will definitely leave your skin. To climb the second highest peak in the United Arab Emirates, [url=https://desertadventuregroup.com/top-rated-attraction-places-of-uae/]Jebel Hafeet[/url] is one of the most popular destinations for tourists and locals alike.<br />[url=https://desertadventuregroup.com/top-rated-attraction-places-of-uae/]beaches at Khor Fakkan[/url] is a must to experience the region’s amazing wildlife reserves. Those who want to visit the wonderful desert islands resort and spa of Anantara or want to enjoy a luxurious meal here.Travel loverhttps://www.blogger.com/profile/04073797292412235051noreply@blogger.comtag:blogger.com,1999:blog-196334975274806517.post-85780744505984131342021-05-03T03:45:10.185-06:002021-05-03T03:45:10.185-06:00He is the King of Thailand. He is the only son of ...He is the King of Thailand. He is the only son of King Bhumibol Adulyadej and Queen Sirikit<br /><a href="https://livenewsheadline.com/maha-vajiralongkorn/" rel="nofollow">Maha Vajiralongkorn Information</a>Hhttps://www.blogger.com/profile/08055065524251296602noreply@blogger.comtag:blogger.com,1999:blog-196334975274806517.post-41402461031498682612020-11-05T13:07:38.218-07:002020-11-05T13:07:38.218-07:00Watch Tamil Tv Series online anytime anywhere thro...Watch <a href="https://tamilsun.net/" rel="nofollow"><strong>Tamil Tv Series</strong></a> online anytime anywhere through YuppTV. 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I think that inflammation is the consequ...Cristian,<br />I think that inflammation is the consequence of multiple inputs. High osmolarity is just one situation that activates NFkB leading to the expression of the suite of genes that produces the inflammatory phenotype at the cellular and tissue levels.<br /><br />I wasn't aware of the buildup of serum materials in tumors, which constitutes hyperosmolarity. I will have to look into it. It is related to vacularization, which is a critical step of tumor development. ( It is interesting that processing of some collagens produces a peptide that blocks vascularization. That is why cartilage doesn't have blood vessels or nerves. Immature cartilage, as in damaged surfaces, fails to suppress vascularization and can lead to pain and fragility.)<br /><br />Perhaps leakiness of newly forming vessels in tumors leads to hyperosmolarity, inflammation and suppression of apoptosis. Tumor survival may depend on both induction of vessels and inhibition of maturation -- the tissue around the tumor is somewhat like the uterine wall and the tumor is the placenta/foreign tissue.<br /><br />Thanks for the interesting perspective.Dr. Art Ayershttps://www.blogger.com/profile/01727664149735013259noreply@blogger.comtag:blogger.com,1999:blog-196334975274806517.post-45147352632861313172009-07-30T13:01:27.314-06:002009-07-30T13:01:27.314-06:00Is hyperosmolarity a synonym of inflammation?
Is ...Is hyperosmolarity a synonym of inflammation?<br /><br />Is inflammation a consequence of extracellular hyperosmolarity?<br />http://www.ncbi.nlm.nih.gov/pubmed/19549308<br /><br />Excerpts:<br /><br />"The present study further suggests inflammation and hyperosmolarity are closely related phenomena if not synonymous."<br /><br />"The consequences of hyperosmolarity may not be limited to inflammation: first, we know that chronic infection and inflammation contribute to about 25% of all cancer cases worldwide [25]; second, hyperosmolarity has also been measured in tumors [26]. This increased oncotic pressure (osmotic pressure exerted by proteins in plasma) has been mostly studied because it prevents the delivery on target of anti neoplastic drugs. Distribution of antineoplastic agents within tumors remains one of the major challenges in cancer chemotherapy because distribution is hampered by high interstitial oncotic pressure [27,28]. It is possible that cancer might also be a consequence of the massive influx of protein leaked first during chronic inflammation and then by the resulting abnormal blood vessels. The resulting increased pressure may play a major role in cancer development. This hypothesis is reinforced by the fact that we show that hyperosmolarity down-regulates the tumor suppressor gene p53 and delays apoptosis."Cristianhttps://www.blogger.com/profile/10896985084617972320noreply@blogger.comtag:blogger.com,1999:blog-196334975274806517.post-35202185486601762162009-07-29T17:33:47.522-06:002009-07-29T17:33:47.522-06:00Thanks for bringing the blue mice cure to my atten...Thanks for bringing the blue mice cure to my attention.<br /><br />I just wrote a quick article for Suite101 on the subject. For some reason, trauma to the spinal column (brain too?) leads to ATP release into the damaged tissue. That causes inflammation through the P2X7 purine receptor. The inflammation ends up killing cells.<br /><br />I think that estrogen protects brain cells from trauma-based inflammation. Maybe it would work in spinal cord injuries. Glycosaminoglycans, GAGs, are also important.Dr. Art Ayershttps://www.blogger.com/profile/01727664149735013259noreply@blogger.comtag:blogger.com,1999:blog-196334975274806517.post-23886513762611059042009-07-29T04:05:05.481-06:002009-07-29T04:05:05.481-06:00http://www.telegraph.co.uk/science/science-news/59...http://www.telegraph.co.uk/science/science-news/5921266/Blue-MandMs-mend-spinal-injuries.html <br /><br />Wondered if you had seen this yet. The anti-inflammatory effect of the blue dye used in blue M&Ms is apparently effective in treating spinal injuries.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-196334975274806517.post-21450303707036277562009-07-29T00:03:50.712-06:002009-07-29T00:03:50.712-06:00Thanks Art!Thanks Art!Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-196334975274806517.post-3162627007720111462009-07-28T13:50:39.077-06:002009-07-28T13:50:39.077-06:00Todd,
I no longer think that saturated fats are a ...Todd,<br />I no longer think that saturated fats are a problem, because they don't seem to contribute significantly to inflammation.<br /><br />If someone is suffering from chronic inflammation, then perhaps extra dietary saturated fats may contribute to problems at local sites of inflammation, e.g. atherosclerotic plaques.<br /><br />If someone can tradeoff saturated fats for omega-6 vegetable oils, I think that would be a good health trade. I would eat butter before corn oil or safflower oil.<br /><br />Thoughts on movement, inflammation and cartilage:<br />Movement is the best lubricant, i.e. lowers inflammatory cytokines, for joints. Avoidance of movement is a symptom of chronic inflammation. Aging is associated with higher chronic inflammation and therefore less movement. Less movement makes joints more prone to inflammation. People who move protect their joints from aging. Joints don't wear out. People just sit.<br />"Young" cartilage does not suppress vascularization. Damaged cartilage is young and fragile. Old people have young joint surface cartilage. Maturation of cartilage requires mechanical stress. People don't age, they flame out.<br /><br />Thanks for your comments.Dr. Art Ayershttps://www.blogger.com/profile/01727664149735013259noreply@blogger.comtag:blogger.com,1999:blog-196334975274806517.post-5212497225880379182009-07-28T13:25:56.501-06:002009-07-28T13:25:56.501-06:00Art,
I have often read that sat fats are pro-inf...Art, <br /><br />I have often read that sat fats are pro-inflammatory but have never seen the mechanism explained and just assumed that this is part of the unfair demonizing of sat fats that we see everywhere. Recently I read that sat fats can activate toll like receptor activity which is pro-inflammatory. Is this an important source of inflammation in your view?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-196334975274806517.post-17271845826903333782009-07-26T22:40:36.277-06:002009-07-26T22:40:36.277-06:00Jean,
Thanks for the link.
That site seems inform...Jean,<br />Thanks for the link.<br /><br />That site seems informative and newsy.<br /><br />My idea was to be less dependent on what actually happens in the White House and more based on an actual health agenda. It could also be done as a fake obama, where everyone knows that is not the pres., but it is still a source of useful info on day-to-day eating. It would definitely attack the status quo. It would be guerilla healthcare, to attack corporate food processing and the agri-health complex.<br /><br />It would simple promote sound food/diet/health practices so that people don't need the corrupt food and healthcare systems. They can be healthier without them.<br /><br />It would be useful to have the Pres' support, but if Obama is too close to healthcare that works, his future will be threatened by all of the powerful lobbies. Functional healthcare is effective and cheap. Maybe Bill Gates would support healthcare for the poor in the US. Maybe a Barack's Breakfast iPhone App with twitter support would be all that is needed.Dr. Art Ayershttps://www.blogger.com/profile/01727664149735013259noreply@blogger.com